Natural killer T (NKT) cells accelerate Shiga toxin type 2 (Stx2) pathology in mice

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Natural killer T (NKT) cells accelerate Shiga toxin type 2 (Stx2) pathology in mice

Shiga toxin-producing Escherichia coli (STEC) is a leading cause of childhood renal disease Hemolytic Uremic Syndrome (HUS). The involvement of renal cytokines and chemokines is suspected to play a critical role in disease progression. In current article, we tested the hypothesis that NKT cells are involved in Stx2-induced pathology in vivo. To address this hypothesis we compared Stx2 toxicity ...

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Structure of shiga toxin type 2 (Stx2) from Escherichia coli O157:H7.

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Extraintestinal pathogenic Escherichia coli carrying the Shiga Toxin gene stx2.

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Promoter Sequence of Shiga Toxin 2 (Stx2) Is Recognized In Vivo, Leading to Production of Biologically Active Stx2

UNLABELLED Shiga toxins (Stx) are the main agent responsible for the development of hemolytic-uremic syndrome (HUS), the most severe and life-threatening systemic complication of infection with enterohemorrhagic Escherichia coli (EHEC) strains. We previously described Stx2 expression by eukaryotic cells after they were transfected in vitro with the stx2 gene cloned into a prokaryotic plasmid (p...

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ژورنال

عنوان ژورنال: Frontiers in Microbiology

سال: 2015

ISSN: 1664-302X

DOI: 10.3389/fmicb.2015.00262